Artificial Cell, Lipid Nanoparticles (LNPs)
"ProtoCell Concept"
Nanoscale self-assembly is imperative in the fabrication of lipid nanoparticles (LNPs). We leverage artificial intelligence (AI) to select lipid compositions that confer LNPs with dual-functionality, which are capable of in vivo targeted delivery of active functional molecules with reduced toxicity effects while offering protection and stabilization to the active functional molecules.
![3-LNP-poster.jpg](https://static.wixstatic.com/media/1c7a06_548bfae5a22e4324a5549e36249ab3ef~mv2.jpg/v1/fill/w_566,h_374,al_c,q_90,enc_auto/3-LNP-poster.jpg)
56
Tae H, Park S, Tan LY, Yang C, Lee YA, Choe YH, Wüstefeld T, Jung S*, and Cho NJ*
"Elucidating Structural Configuration of Lipid Assemblies for mRNA Delivery Systems"
55
Sut TN, Park S, Jackman JA**, Cho NJ**
(** denotes equal corresponding authors)
"Controlling molecular self-assembly of inverse-phosphocholine lipids at oxide interfaces with divalent cations"
54
Hyeonjin Park, Tun Naw Sut, Bo Kyeong Yoon, Vladimir P. Zhdanov, Nam-Joon Cho*, and Joshua A. Jackman*
53
Sut TN, Ferhan AR, Park S, Koo DJ, Yoon BK, Jackman JA*, and Cho NJ*
Applied Materials Today, 2022, 29: 101618.
52
Ferhan AR, Park S, Park H, Tae H, Jackman JA*, Cho NJ*
"Lipid Nanoparticle Technologies for Nucleic Acid Delivery: A Nanoarchitectonics Perspective."
Advanced Functional Materials, 2022: 2203669.
51
Park H, Sut TN, Yoon BK, Zhdanov VP, Kim JW, Cho NJ*, Jackman JA*
The Journal of Physical Chemistry Letters, 2022, 13: 1480-1488.
50
Tae H, Park S, Ma GJ, Cho NJ
"Nanoarchitectured air-stable supported lipid bilayer incorporating sucrose–bicelle complex system."
Nano Convergence, 2022, 9: 3.
49
Sut TN, Yoon BK, Jeon WY, Jackman JA*, Cho NJ*
(* denotes equal corresponding authors)
"Supported Lipid Bilayer Coatings: Fabrication, Bioconjugation, and Diagnostic Applications."
Applied Materials Today, 2021, 25: 101183.
48
Tan JYB*, Yoon BK*, Cho NJ, Lovrić J, Jug M, Jackman JA
(* denotes equal first authors)
"Lipid Nanoparticle Technology for Delivering Biologically Active Fatty Acids and Monoglycerides."
International Journal of Molecular Sciences, 2021, 22(18): 9664.
47
Yoon BK, Sut TN, Yoo KY, Lee SH, Hwang Y, Jackman JA*, Cho NJ*
(* denotes equal corresponding authors)
"Lipid Bilayer Coatings for Rapid Enzyme-Linked Immunosorbent Assay."
Applied Materials Today 2021, 24: 101128.
46
Park H*, Sut TN*, Yoon BK, Zhdanov VP, Cho NJ**, Jackman JA**
(* denotes equal first authors, ** denotes equal corresponding authors)
"Unraveling How Multivalency Triggers Shape Deformation of Sub-100 nm Lipid Vesicles."
Journal of Physical Chemistry Letters, 2021, 12: 6722-6729.
45
Jackman JA, Cho NJ
"Supported Lipid Bilayer Formation: Beyond Vesicle Fusion."
Langmuir 2020; 36, 6,1387-1400.
44
Ho JCS, Steininger C, Hiew SH, Kim MC, Reimhult E, Miserez A, Cho NJ, Parikh AN, Liedberg B
Cover Illustration
"Minimal Reconstitution of Membranous Web Induced by a Vesicle-Peptide Sol-Gel Transition."
Biomacromolecules 2019; 20, 4, 1709-1718.
43
Emilsson G, Röder E, Malekian B, Xiong K, Tsai FC, Cho NJ, Bally M, Dahlin A
"Nanoplasmonic Sensor Detects Preferential Binding of IRSp53 to Negative Membrane Curvature."
Frontiers in Chemistry 2019; 7(1), 1-8.
42
Ferhan AR, Špačková B, Jackman JA, Ma GJ, Sut TN, Homola J, Cho NJ
Analytical Chemistry 2018; 90(21), 12503-12511.
41
Biswas K, Cho NJ, Groves JT
Langmuir 2018; 34(33), 9781-9788.
40
Meker S, Chin HK, Sut TN, Cho NJ
Langmuir 2018; 34(32), 9548-9560.
39
Ferhan AR, Jackman JA, Malekian B, Xiong K, Emilsson G, Park S, Dahlin AB, Cho NJ
Analytical Chemistry 2018; 90(12), 7458-7466.
38
Biswas KH, Jackman JA, Park JH, Groves JT, Cho NJ
Langmuir 2018; 34(4), 1775-1782.
37
Gillissen JJ, Jackman JA, Tabaei SR, Cho NJ
Analytical Chemistry 2018; 90(3), 2238-2245.
36
Gillissen JJ*, Tabaei SR*, Jackman JA, Cho NJ
(* denotes equal first authors)
"Effect of Glucose on the Mobility of Membrane-Adhering Liposomes."
Langmuir 2018; 34(1), 503-511.
35
Gillissen JJ, Jackman JA, Tabaei SR, Yoon BK, Cho NJ
Analytical Chemistry 2017; 89(21), 11711-11718.
34
Gillissen JJ, Tabaei SR, Jackman JA, Cho NJ
Cover Illustration
Analyst 2017: 142(18), 3370-3379.
33
Ferhan AR, Ma GJ, Jackman JA, Sut TN, Park JH, Cho NJ
Sensors 2017; 17(7), 1484.
32
Ferhan AR, Jackman JA, Cho NJ
Analytical Chemistry 2017: 89(7), 4301-4308.
31
Ferhan AR, Jackman JA, Cho NJ
Physical Chemistry Chemical Physics 2017: 19(3), 2131-2139.
30
Jackman JA, Yorulmaz Avsar S, Ferhan AR, Li D, Park JH, Zhdanov VP, Cho NJ
Analytical Chemistry 2017: 89(2), 1102-1109.
29
Ferhan AR, Jackman JA, Cho NJ
Analytical Chemistry 2016: 88(24), 12524-12531.
28
Tabaei SR, Gillissen JJ, Cho NJ
Cover Illustration
Small 2016; 12, 6338–6344.
27
Tabaei SR, Gillissen JJ, Block S, Hook F, Cho NJ
ACS Nano 2016; 10(9), 8812-8820.
26
Tabaei SR, Gillissen JJ, Vafaei S, Groves JT, Cho NJ
"Size-Dependent, Stochastic Nature of Lipid Exchange Between Nano-Vesicles and Model Membranes."
Nanoscale 2016; 8(27), 13513-13520.
25
Dacic M*, Jackman JA*, Yorulmaz S, Zhdanov VP, Kasemo B, Cho NJ
(* denotes equal first authors)
"Influence of Divalent Cations on Deformation and Rupture of Adsorbed Lipid Vesicles."
Langmuir 2016; 32(25), 6486-6495.
24
Tabaei SR, Gillissen JJ Kim MC, Ho JCS, Liedberg B, Parikh AN, Cho NJ
Langmuir 2016; 32(21). 5445-5450.
23
Jackman JA, Kim MC, Zhdanov VP, Cho NJ
Physical Chemistry Chemical Physics 2016; 18(4), 3065-3072.
22
Kim MC, Gunnarsson A, Tabaei SR, Höök F, Cho NJ
"Supported Lipid Bilayer Repair Mediated by AH Peptide."
Physical Chemistry Chemical Physics 2016; 18(4), 3040-3047.
21
Jackman JA, Špačková B, Linardy E, Kim MC, Yoon BK, Homola J, Cho NJ
Cover Illustration
"Nanoplasmonic Ruler to Measure Lipid Vesicle Deformation."
Chemical Communications 2016; 52(1), 76-79.
20
Jeong JH, Choi JH, Kim MC, Park JH, Herrin JS, Kim SH, Lee H, Cho NJ
European Biophysics Journal 2015; 44(5), 383-391.
19
Tabaei SR, Cho NJ
Cover Illustration
"Lamellar Sheet Exfoliation of Single Lipid Vesicles by a Membrane-Active Peptide."
Chemical Communications 2015; 51(51), 10272-10275.
18
Oh EK*, Jackman JA*, Yorulmaz S, Zhdanov VP, Lee H, Cho NJ
(* denotes equal corresponding authors)
Langmuir 2014; 31(2), 771–781.
17
Wallin M, Choi JH, Kim SO, Cho NJ, Andersson M
"Peptide‑induced Formation of a Tethered Lipid Bilayer Membrane on Mesoporous Silica."
European Biophysics Journal 2015; 44(1-2), 27-36.
16
Jackman JA, Zhdanov VP, Cho NJ
Langmuir 2014; 30(31), 9494–9503.
15
Goh HZ*, Jackman JA*, Kim SO, Cho NJ
Cover Illustration
(* denotes equal first authors)
"Controlling Lipid Membrane Architecture for Tunable Nanoplasmonic Biosensing."
Small 2014; 10(23), 4828-4832.
14
Goh HZ, Cho NJ
Colloids and Surfaces B: Biointerfaces 2014: 121, 340-346.
13
Jackman JA, Goh HZ, Zhao Z, Cho NJ
"Contribution of the Hydration Force to Vesicle Adhesion on Titanium Oxide."
Langmuir 2014; 30(19), 5368–5372.
12
Goh HZ*, Jackman JA*, Cho NJ
(* denotes equal first authors)
"AH Peptide-Mediated Formation of Charged Planar Lipid Bilayers."
The Journal of Physical Chemistry B 2014; 118(13), 3616-3621.
11
Jackman JA, Zhao Z, Zhdanov VP, Frank CW, Cho NJ
"Vesicle Adhesion and Rupture on Silicon Oxide: Influence of Freeze-Thaw Pretreatment."
Langmuir 2014; 30(8), 2152-2160.
10
Jackman JA, Choi JH, Zhdanov VP, Cho NJ
"Influence of Osmotic Pressure on Adhesion of Lipid Vesicles to Solid Supports."
Langmuir 2013; 29(36), 11375-11384.
09
Cho NJ*, Hwang LY, Solandt JJR, Frank CW*
(* denotes equal corresponding authors)
"Comparison of Extruded and Sonicated Vesicles for Planar Bilayer Self-Assembly."
Materials 2013; 6(8), 3294-3308.
08
Jackman JA, Knoll W, Cho NJ
"Biotechnology Applications of Tethered Lipid Bilayer Membranes."
Materials 2012; 5(12), 2637-2657.
07
Cho NJ, Jackman JA, Liu M, Frank CW
Langmuir 2011; 27(7), 3739-3748.
06
Claesson M, Cho NJ, Frank CW, Andersson M
"Vesicle Adsorption on Mesoporous Silica and Titania."
Langmuir 2010; 26(22), 16630-16633.
05
Cho NJ, Frank CW
"Fabrication of a Planar Zwitterionic Lipid Bilayer on Titanium Oxide."
Langmuir 2010; 26(20),15706-15710.
04
Cho NJ, Frank CW, Kasemo B, Höök F
Nature Protocols; 5(6), 1096-1106.
03
Jackman JA, Cho NJ, Duran RS, Frank CW
Langmuir 2010; 26(6), 4103-4112.
02
Cho NJ, Wang G, Edvardsson M, Höök F, Frank CW
Analytical Chemistry 2009; 81(12), 4752-4761.
01
Cho NJ, Kanazawa KK, Glenn JS, Frank CW
Cover Illustration
Analytical Chemistry 2007; 79(18), 7027-7035.