Publications | Engineering in Translational Science

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Complement-activation related Pseudoallergy
(CARPA)

CARPA
"Next-Generation Measurement Assay for Nanomedicine"

Complement-activation related pseudoallergy (CARPA) is a potentially lethal acute immune toxicity caused by many intravenous drugs that contain nanoparticles or proteins. The integration of our group’s biomimetic membrane platform with state-of-the-art surface-based characterization tools has led to a promising new approach for real-time monitoring and better understanding of the complement activation process.

06

Fülöp TG, Nemes R, Mészáros T, Urbanics R, Kok RJ, Jackman JA, Cho NJ, Storm G, Szebeni J

"Complement Activation In Vitro and Reactogenicity of Superparamagnetic Iron-Oxide MRI Contrast Agents in Pigs: Correlation with Physicochemical Features and Clinical Information."

Journal of Controlled Release 2017; 270, 268-274.

05

Yorulmaz Avsar S, Jackman JA, Kim MC, Yoon BK, Hunziker W, Cho NJ

"Immobilization Strategies for Functional Complement Convertase Assembly at Lipid Membrane Interfaces."

Langmuir 2017; 33(29), 7332-7342.

04

Yorulmaz S, Jackman JA, Hunziker W, Cho NJ

"Influence of Membrane Surface Charge on Adsorption of Complement Proteins onto Supported Lipid Bilayers."

Colloids and Surfaces B: Biointerfaces 2016; 148, 270-277.

03

Jackman JA, Mészáros T, Fülöp T, Urbanics R, Szebeni J*, Cho NJ*

"Comparison of Complement Activation-Related Pseudoallergy in Miniature and Domestic Pigs: Foundation of a Validatable Immune Toxicity Model."

Nanomedicine: Nanotechnology, Biology, and Medicine 2016; 12(4), 933-943.

02

Yorulmaz S, Jackman JA, Hunziker W, Cho NJ

"Supported Lipid Bilayer Platform to Test Inhibitors of the Membrane Attack Complex: Insights into Biomacromolecular Assembly and Regulation."

Biomacromolecules 2015; 16(11), 3594-3602.

01

Yorulmaz S, Tabaei SR, Kim MH, Seo JE, Hunziker W, Szebeni J, Cho NJ

"Membrane Attack Complex Formation on a Supported Lipid Bilayer: Initial Steps towards a CARPA Predictor Nanodevice."

European Journal of Nanomedicine 2015; 7(3), 245-255.

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